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Skin Cancer Causes

Do you know what skin cancer is? It’s one of the most common cancer in the world and surely will make you in a horrible state once you got this kind of disease. There are something which can causes skin cancer, including UV light. Ultraviolet (UV) radiation can damage DNA. Sometimes this damage affects certain genes that control how and when cells grow and divide. If these genes do not function properly, the affected cells may form a cancer.

Most UV radiation comes from sunlight, but some may come from man-made sources such as tanning booths. Usually it’s not clear exactly when UV exposure causes DNA damage that might eventually lead to cancer. Some of the damage may take place in the few years before the start of the cancer. But much of it may be due to exposures that happened many years earlier.

In some families with inherited melanomas, gene mutations that greatly increase the risk of melanoma are passed from one generation to the next. Familial (inherited) melanomas most often have changes in tumor suppressor genes such as CDKN2A (also known as p16) and CDK4 that prevent them from doing their normal job of controlling the growth of the cell. Scientists reason that this leads to overgrowth and eventually cancer.

Although most moles never turn into a melanoma, some do. Researchers have found some DNA changes that transform benign nevus (mole) cells into melanoma cells. But it is still not known exactly why some moles become cancerous or why having many moles or atypical (dysplastic) moles increases your risk of developing melanoma.

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